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Practically insoluble in water. Sparingly soluble in ethanol, chloroform, ether. It is soluble in alkaline solutions. Pharmacology Mode of action — anti-inflammatory, antipyretic, analgesic.
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It passes through the BBB. Not removed by hemodialysis.
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There were no mutagennocti indomethacin in some bacterial tests in vitro Ames test, the test with E. In the reproduction studies, including two generations, at dose levels up to 0. Rectally Inflammatory and degenerative diseases of the musculoskeletal — musculoskeletal system: Algomenorrhea, to maintain pregnancy, Bartter syndrome secondary hyperaldosteronism, pericarditis symptomatic treatment, childbirth as analgesic and tocolytic agent in preterm labor, inflammation of the pelvis, including adnexitis, cleft arterial duct. Infectious — inflammatory diseases of ENT — organs with marked pain can You Buy Generic Indomethacin In The Usa in the complex therapy: Inflammatory and degenerative diseases of the musculo — skeletal system deforming osteoarthritis, rheumatoid can You Buy Generic Indomethacin In The Usa, psoriatic arthritis, rheumatoid arthritis, frozen shoulder, ankylosing spondylitis, low back pain with radicular syndrome except for degenerative disease of the hip joints.
In ophthalmology eye drops: In dentistry systemic and cutaneous application: Contraindications for systemic use: Restrictions on the use For cutaneous application. In ophthalmology eye drops.
Application of pregnancy and breastfeeding Teratogenic effects of teratogenicity studies conducted in rats and mice at doses of 0. Comparative study in rodents using high doses of aspirin showed similar effects in females and their fetuses.
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However, reproductive studies in animals do not always predict effects in humans. Adequate and well-controlled studies in pregnant women have not done.
Vascular system of the fetus premature closure of the orangeconcept.vn arteriosus, the use should be avoided during pregnancy especially in the later stages. At a dose of 2. Category effects on the fetus by FDA ; C. Indomethacin passes into breast milk, so breast-feeding should be discontinued during treatment and avoid the use of indomethacin during breastfeeding.
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Ethanol, colchicine, corticosteroids and corticotropin increase the risk of bleeding in the gastrointestinal tract. Cyclosporine and gold preparations increase the nephrotoxicity due to suppression of PG synthesis in the kidneys. Cefamandole, ceftazidime, tsefotetan, valproic acid ; gipoprotrombinemii increase the incidence of, and risk of bleeding. Antacids and cholestyramine reduce the absorption of indomethacin.
Enhances AZT toxicity due to inhibition of metabolism, in newborns an increased risk of toxic effects of aminoglycosides as reduced renal clearance and increases in blood concentration. Indomethacin may reduce the antihypertensive effect of captopril and losartan.
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